Impact of Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Cardiovascular Research

Despite having therapeutic advances in the medical fields, we continue to receive destructive outcomes for the patients with cardiovascular diseases. Not only have cardiovascular disorders such as myocardial infarction causing congestive heart failure, become a growing concern for every individual, it emerges as one of the sole cause of deaths in Western Countries.

However, we have too many evidences from clinical trials and medical research, which prove the efficacy and potentiality of stem cell based therapies in treating cardiovascular disorders. They are capable of fostering revascularization of cardiac tissues, regenerating cardiac tissues and also reinstating the cardiac performances.

With several recent experimental studies finding success through the use of different stem cell populations, it raises promising hopes for the patients of a complete relief from the severity of the diseases, and also heavy medical bills. In recent times, there have been a huge application of skeletal myoblasts, embryonic stem cells, endothelial progenitor cells, hematopoietic stem cells and not to mention- the mesenchymal stem cells in biomedical research for the development of regenerative therapies.

That apart, another study in the recent times has showcased a positive outcome for the treatment of cardiovascular disorders using human umbilical cord-derived mesenchymal stem cells.

While human umbilical cord derived stem cells are a useful tissue for combating various adamant diseases, it has become a great potential for us to save these cells through UCB banking, giving us an equal opportunity for future use. As UCB banking provides us with opportunities to preserve these precious cells, the growth of the UCB banking is on the surge as well. Notwithstanding, it is worth discovering the efficacy and importance of UCB mesenchymal stem cells on cardiovascular research, and finding more promises for our health care.

Why UCBMSCs Are A Useful Component In The Research Of Cardiovascular Diseases

MSCs have unique properties to differentiate into a myogenic phenotype in vitro, hence it is capable of alleviating the symptoms of ischemic and nonischemic related cardiac complications. Another study suggested that bone marrow derived autologous MSCs have properties like cardiomyocyte like cells, which reinstated the cardiac functions of a rat with cryoinjury.

And because of this wide array of advantages of MSCs in the heart related complications, UCBMSCs are constantly being used in the research to develop effective strategies to be used for relieving cardiovascular disorders.

In addition to this, for immune deficiency disorders and human blood related diseases, UCB cells has shown some potential properties to replace the HPCs in the clinical setting as a source for research since 1988. At the same time, these cells derived from UCB contain the properties of MSCs as well, and therefore they are effective in treating idiopathic dilated cardiomyopathy as well.

We can have a clearer insight through an investigation theory carried out on mice at the most recent time into the efficacy of UCBMSCs.

Clinical Methods

Mice with cardiac infarction, including healthy mice received UCB mononuclear cells infused with CD34- positive cells through a transplantation. They were observed for 3 weeks.

It was found that both healthy and infracted mice had received UCB cells to their liver, spleen and bone marrow. However, only the mice with cardiac issues had transplanted cells on their hearts. A reduced heart size, coupled with collagen deposits and increased capillary density were signs of their myocardial infarction.

Therefore, this result of the study showed that UCBMSCs have the potential to return to the infarcted heart with transplantation and aid in the growth of heart tissues.

Proven Benefits of Fish Oil You Need to Know About

Consumption of fast food, deep fried snacks results in the accumulation of cholesterol in the arteries that led to fatal health issues like heart attack and strokes. These calorie-rich foods also have a significant contribution to the nation’s increasing rate of obesity. Besides consulting a physician or shedding sweat in the gym it is equally important to include a healthy diet and maintain a systematic lifestyle.

Intake of cold water fishes like salmon, herring, and sardines rich in Omega3 fatty acids helps in eliminating LDL- low- density lipoprotein (bad cholesterol) and oil extracted from fish is considered as one of the potent sources of omega3 fatty acids. Markets are flooded with many omega3 supplements but it is always beneficial to extract from the natural sources.

Fish oil offers a wide range of benefits to many health ailments which have been clinically proven. Consumption of the oil derived from fish’s liver helps in getting rid of depression, tension, arthritis, weight loss and many more. Let’s talk about some proven health benefits of the oil.

• Lower heart risks: The oil is considered as the best caretaker of the heart. The Omega3 fatty acids help in combating the bad cholesterol which higher the risk of heart attacks and related disease and also help in maintaining the normal heart rate.

• Fights cancer: Being a rich source of long-chain omega3 fatty acids, fish oil has the potential to blunt the production of Cox- 2 derived prostanoids in cancer cells. The two components of fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) plays a valuable role in cancer treatment.

• Treats Alzheimer’s: From various studies, it has been proved that the fatty acid in the oil is essential for proper brain functioning and its long-term consumption by the adults may prevent brain shrinkage.

• Anxiety: Oil from fish is considered as an essential food for the healthy brain development during the growth period of a human being because providing fish to the kids at this stage will keep them away from stress and anxiety.

• Depression: To get rid of depression and mood disorders oil extracted from fish works as a magic wand. This oil can fight depression and effectively improves emotional well being.

• Fertility & pregnancy: Research proves that mothers who included liver oil of the fish in their diet during pregnancy gave birth to the children with great problem-solving skills in addition with good hair and skin.

• Fight Diabetes: New research suggests that oil derived from fish is capable of reducing the risk of diabetes by reducing oxidative stress which plays a crucial role in the development of diabetes. That is why this oil is now prescribed in the diabetic diet plan.

• Good for eyes: Dry eyes are the most common problem today and the omega3 in the fish oil helps in producing oil in the meibomian gland in the eyelids which floats across the eye keeping the eye moisturize with the tears and prevents it from getting evaporated.

• Good skin and hair: The fatty acid in the oil extracted from fish nourishes the skin and keeps the skin smooth with an elastic texture. The fatty acids contain EPA and DHA which prevents conditions like dandruff, eczema, and psoriasis and is a much essential component in keeping the skin and hair moisturized.

• Weight Loss: Fish oil can magically help to get rid of obesity. The omega3 help in fat oxidation by breaking down the fat molecules into fatty acids and triglycerides thereby mobilizing the fat and also helps in building muscles.

• Improves immune system: Omega3 in the oil helps in enhancing the functioning of the immune cells. Salmon is the ideal fish whose oil and astaxanthin works as the ultimate immune boosting health food.

• Inflammation: The process of fighting infection and healing injuries by our immune system is inflammation. Oil from fish contains anti-inflammatory properties that treat chronic inflammation.

• Fight bone disease: The omega3fatty acids contain in the oil of fishes like sardine, tuna, salmon helps in bone growth with higher density that prevents various bone disease. However, the effect may vary with the intake of supplements.

Conclusion: The benefits of fish oil has been proved clinically as essential components in fighting many health disorders but for the patients it is very important to go for proper medical diagnosis before undergoing any such dietary treatment.

Common Private Cord Blood Banking Myths Debunked

You may have noticed that there is a lot of marketing and promotions done by banks nowadays. But what is a cord blood bank exactly? Well, it is a medical bank where doctors extract the hematopoietic stem cells (HSCs) from the newborn umbilical cord and can be preserved indefinitely. You can bank the blood in a private or a public one and can be used later on to treat diseases and illnesses. This may sound like a wonderful medical breakthrough, but there are many myths about private cord blood banking making the rounds. Let us have a look at these myths and break the misconceptions clouding the minds of parents-to-be.

1. Can It Harm My Baby Be Harmed?

Collection of this is in no way harmful to the baby or the mother. The blood that is discarded after birth normally is collected and stored at bank.

2. Private Cord Blood Banks May Send Our Baby’s Cord Blood for Research

This is a complete myth as private cord blood banks give exclusive accessibility and control to what you store. They charge you annually for storing this and will give you access as and when you require it in the future. Unlink public banks wherein the blood may be sent further for research purposes.

3. Choose Any Bank, They Are All the Same

Wrong. Private blood banks have to follow stringent norms in terms of quality, cost, location, and need to be FDA-approved and AABB-accredited. However, not all private ones have DA approval and AABB-accreditation. Those who have both, have high annual storage fees and better facilities to store your baby’s cord blood for a longer duration.

4. It is Always Better to Store Cord Blood in Private Banks

Many to-be parents often think storing their baby’s cord blood in private banks is better than donating it to a public bank. If your family has a history of certain diseases and disorders, then choosing a private blood bank may sound logical. However, there is no such history and you don’t even know if you will ever need to access the stored this, then donating this to a public bank is a wise decision.

5. You Can’t Treat Your Child With His/ Her Own Blood as it May Be Diseased Itself

This statement does not hold much ground as autologous transplants have been in use for more than a decade. Use of one’s own stem cells has helped in the treatment of many diseases ranging from neuroblastoma, lymphoblastic leukemia, etc.

6. This Blood can Remain Viable Only for 10 Years

Current studies have shown, stem cells stored for about 24 years remained viable without any decrease in viability or proliferation. It is even claimed by cryopreservationists these cells can be stored indefinitely in a controlled environment.

7. Cord Blood Banking And Ethical Issues

According to the Indian Council of Medical Research (ICMR), there are certain issues related to the self-use of blood as promoted by such banks. The ICMR guidelines for stem cell research (2013) states there is no scientific basis for preservation of this for future self-use. Thus, this practice is not officially recommended and any use other than bone marrow transplantation apart from clinical trials is termed as a medical malpractice.

8. You Can Decide About Cord Blood Banking Just Before You Deliver

It is not a good idea to make a last-minute decision in most of the cases. Your hospital may not have the collection kit ready during the child’s birth. There are many logistics that need to be figured out before you can store this. Thus, make sure you enroll early to this of your choice for smooth and hassle free collection during the birthing process.